Figure 8

Response of the double DIFFL to a bursting signal. The motif of double DIFFL (Fig. 1(f)) is stimulated with 3 different periodic input signals X(t) (on the left). The 3 graphs on the right give the response of the output W (t). The numerical simulations were done with the following parameters τ₁ = 100 s and τ₂ = 10000 s are fixed. The other parameters are: α₁ = 0.01 sec^-1, β₁ = 10 nM.sec^-1, α₂ = 0, 006 min^-1 β₂ = 6 min^-1, θ₁ = θ₅ = 700 nM, θ₂ = θ₆ = 800 nM, θ₃ = θ₄ = 50 nM. (a) with σ₁ = 0 s, σ₂ = 100 min (b) with σ₁ = 60 s, σ₂ = 0 min (c) σ₁ = 60 s, σ₂ = 100 min. For practical reasons, the representations of the pulsatile signals are not at real scale.