Figure 1

(Color) Protein make-up of the yeast complexes. (a) Each horizontal line represents one complex, and its color is determined by the RGB scheme, where the green component of the line color is the fraction of complex subunits which are constant proteins, the blue is the fraction of rich-state proteins, and the red is the fraction of minimal state proteins. For real complexes (left panel), many complexes show almost pure base colors, corresponding to complexes in which all (or most) of the proteins belong to the same class. Following shuffling of the protein classes (right panel), colors tend to be mixed, indicating mixture of proteins of different classes. (b) Uniformity in change of protein levels in complexes between YEPD and SD states. For each complex, we calculated the largest of the three fractions of its subunits that exhibited increase, decrease or no change upon a change between YEPD and SD states. In the figure, we plot the distribution of this fraction among all complexes for real complexes and after shuffling of the protein complexes (averaged over 100 randomizations). For real complexes, typically a large fraction of the subunits change uniformly, in contrast to the situation for the shuffled ones (p-value ≈ 10^-11, Kolmogorov-Smirnoff test).