Figure 2

Schematic of the receptor activated ERK pathway. This schematic has been split into a number of distinct sections or patches which are: (1) Blue: the core patch consisting of ligand/receptor binding and the core ERK pathway; (2) Green: the Ras pathway which links bound receptors to ERK activation; (3) Red: the Rap1 pathway which links bound receptors to ERK activation; (4) Orange: the negative feedback loop from ERK to SOS via Rsk; and (5) Purple; the Akt pathway. In the schematic, links which end in arrows represent activating reactions whilst links which end in diamonds represent deactivating reactions.