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Figure 5 | BMC Systems Biology

Figure 5

From: Version control of pathway models using XML patches

Figure 5

Simulations of cancerous mutation. This chart contains simulation traces of the EGF receptor system model with and without a RasV12 cancerous mutation. The x-axis represents time in minutes whilst the y-axis represents the concentration of active ERK in molecules/cell. The blue line represents the simulated level of active ERK from the original Brown EGF model with the normal Ras pathway patch, whilst the red line represents simulated active ERK with a cancerous RasV12 pathway patch. As can seen, swapping the normal Ras patch for a cancerous patch results in the constitutive activation of ERK which would lead to uncontrolled cell growth. The green line represents the simulated level of active ERK with the cancerous RasV12 patch and a hypothetical drug which increasing the catalytic activity of PP2A by a factor of 10. As can be seen, the drug is successful at treating the cancer as it brings active ERK down to basal levels.

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