Table 1 Top scoring maps for a combined set of differentially expressed genes and topologically significant proteins.
From: Identifying disease-specific genes based on their topological significance in protein networks
Map | Map Folders | Cell process | p-value | Genes |
|---|---|---|---|---|
IFN gamma signaling pathway | Immune response | cytokine and chemokine mediated signaling pathway, immune response | 1.88E-26 | 32/63 |
Prolactin receptor signaling | Growth factors | intracellular receptor-mediated signaling pathway, response to hormone stimulus | 4.57E-24 | 30/62 |
Regulation of G1/S transition (part 2) | Cell cycle control | cell cycle | 3.30E-22 | 22/33 |
Chemokines and adhesion | Cell adhesion | cytokine and chemokine mediated signaling pathway, cell adhesion | 6.46E-22 | 45/174 |
EGF signaling pathway | Epidermal cell differentiation | intracellular receptor-mediated signaling pathway, response to extracellular stimulus | 4.89E-21 | 28/64 |
PDGF signaling via STATs and NF-kB | Growth and differentiation | intracellular receptor-mediated signaling pathway, response to extracellular stimulus | 5.18E-21 | 23/40 |
IGF-RI signaling | Growth and differentiation | intracellular receptor-mediated signaling pathway, response to extracellular stimulus | 1.63E-20 | 29/72 |
AKT signaling | Function groups/Kinases | protein kinase cascade | 5.96E-19 | 25/57 |
TGF, WNT and cytoskeletal remodeling | Cell adhesion | cell adhesion | 6.15E-19 | 45/204 |