TY - JOUR AU - Shimamura, Teppei AU - Imoto, Seiya AU - Yamaguchi, Rui AU - Fujita, André AU - Nagasaki, Masao AU - Miyano, Satoru PY - 2009 DA - 2009/04/22 TI - Recursive regularization for inferring gene networks from time-course gene expression profiles JO - BMC Systems Biology SP - 41 VL - 3 IS - 1 AB - Inferring gene networks from time-course microarray experiments with vector autoregressive (VAR) model is the process of identifying functional associations between genes through multivariate time series. This problem can be cast as a variable selection problem in Statistics. One of the promising methods for variable selection is the elastic net proposed by Zou and Hastie (2005). However, VAR modeling with the elastic net succeeds in increasing the number of true positives while it also results in increasing the number of false positives. SN - 1752-0509 UR - https://doi.org/10.1186/1752-0509-3-41 DO - 10.1186/1752-0509-3-41 ID - Shimamura2009 ER -