Figure 4

Characterization of G6PD genetic variants as functions of transport fluxes. The steady state flux differences were calculated for the nRBC and the vRBC variants considered at high and low redox loads for each case, respectively. The SNP variants were then normalized with respect to the flux differences for the normal case. There is a range of clinical phenotypes exhibited in these patients, determined by the severity of their hemolytic disorders. The A minus and A plus variants exhibit a more mild phenotype with non-chronic hemolytic anemia. The transport fluxes for these cases are effectively the same as the nRBC. In contrast, the other variants, with more severe phenotypes, have altered steady state flux differences compared to the normal case. Abbreviations: LEX: lactate transport, HXEX: hypoxanthine transport, INOEX: inosine transport, ADEEX: adenine transport, ADO: adenosine transport.