Figure 2

Receiver operating characteristic (ROC) curve. A graphical representation of the sensitivity versus (1-specificity) comparing environmental factor-phenotype predictions at different p-value cutoffs to a manually curated set of direct chemical-disease relationships from the Comparative Toxicogenomics Database [16] using either specific diseases or broad categorizations of diseases. The SEPEA pathway enrichment p-value cutoff of 0.003 is indicated with arrows for each analysis.