Genetic and environmental pathways to complex diseases

BMC Systems Biology

Table 1 Global gene expression datasets utilized for validation of metabolic syndrome and neuropsychiatric subnetworks

METABOLIC SYNDROME
Condition	Species	Tissue	GEO Acc.	Reference
obese/lean	Human	adipocytes	GSE2508	[30]
obese/lean	Mouse	adipocytes	GSE4692	[31]
Familial combined hyperlipedemia	Human	monocytes	GSE11393	[32]
*Treatment*	*Species*	*Tissue*	*GEO Acc*.	*Reference*
Fenofibrate	Rat	liver	GSE8251	[33]
4-hydroxyphenylretinamide	Rat	liver	GSE3952	[34]
9-cis retinoic acid	Rat	liver	GSE3952	[34]
Targretin	Rat	liver	GSE3952	[34]
Vitamin A deficient diet	Rat	liver	GSE1600	[35]
Omega 3 fatty acids	Rat	cardiomyocytes	GSE4327	[36]
Thiazolidinediones	Human	3T3-L1 adipocytes	GSE1458	[37]
Atorvastatin	Human	monocytes	GSE11393	[32]
Cyfluthrin	Human	astrocytes	GSE5023	[38]
NEUROPSYCHIATRIC DISORDERS
*Condition*	*Species*	*Tissue*	*GEO/EBI Acc*.	*Reference*
Bipolar Disorder	Human	prefrontal cortex	GSE12654	[39]
Depression	Human	prefrontal cortex	GSE12654	[39]
Schizophrenia	Human	prefrontal cortex	GSE12654	[39]
Schizophrenia	Human	frontal cortex	E-MEXP-857	[40]
Anxiety	Mouse	various brain regions	GSE3327	[41]
Autism	Human	lymphoblastoid cell lines	GSE7329	[42]
Autism	Human	whole blood	GSE6575	[43]
*Treatment*	*Species*	*Tissue*	*GEO Acc*.	*Reference*
Chlorpyrifos	Human	astrocytes	GSE5023	[38]
Chlorpyrifos	Rat	forebrain	GSE9751	[44]

ISSN: 1752-0509