Figure 11

The best fit of all reversible deterministic and the Langevin models. Shown are the Langevin model, the measurements, and all reversible deterministic models. For a better visualization, splines are added to the data as well to help imagin how a perfect model curve would look. However, as can be seen, biological measurement data always shows fluctuations. The splines shown here are uncoupled, one individual spline for each metabolite. Thus, there is no underlying biological model motivating these curves. The irreversible models mostly result in straight lines through the data and are hence biologically implausible. For the sake of a clearer recognition of the reversible models, we omit these curves from the plot, [see Additional file 2] for the irreversible models.