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Figure 5 | BMC Systems Biology

Figure 5

From: The Symbiosis Interactome: a computational approach reveals novel components, functional interactions and modules in Sinorhizobium meliloti

Figure 5

Targeted novel proteins and experimental validation. (A) Visualization of the four novel predicted proteins selected for experimental validation based on four different network scenarios: direct-high, direct-low, direct-low module, and indirect-high module scenarios. Only direct interactors of the targeted proteins are represented but for the last scenario that involves indirect interactions. The colours of each protein indicate the stage of symbiosis or phenotypic profile categories the proteins belong to (see panel). Large coloured ovals indicate functional modules with different colours indicating their involvement in different clusters. The colours of each protein as in Fig. 4. Edges are colored according to the probability of interaction, from blue (less probability) to red (more probability). We used Biolayout for network visualization. (B) Nodulation assays of different mutants compared to S. meliloti 1021 wild type strain. Results are expressed as number of nodules per plant. Bars represent the average of three independent experiments (see methods). Red bar stands for control experiments, and blue bars for the four genes tested in this study.

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