Table 3 Significant network communities that are enriched with target genes of miRNA clusters.
From: Clustered microRNAs' coordination in regulating protein-protein interaction network
Chr | Cluster | Network Community | Function |
|---|---|---|---|
3(-) | let-7 | ACTA1, DRP2, SNTA1, DMD, DAG1, SNTB2, UTRN, SNTG1, SNTG2, KCNJ12, SNTB1, PGM5P1, DTNA, DTNB, DGKZ | muscle development and contraction |
13(+) | mir-17 | AR, ESR1, RB1, TP53, CREBBP, EP300, JUN, STAT3, NCOA1, SMAD4, SMAD2, SMAD3, BRCA1, STAT1, TRIP4, RELA, CCND1, SP1 | positive regulation of transcription |
14(+) | mir-379 | ARNTL, PER1, TIMELESS, CRY1, CLOCK, PER3, CRY2, PER2, CSNK1D, CSNK1E | circadian rhythm |
19(+) | mir-512 | HDAC2, RBBP7, RBP1, SAP30, HDAC1, ING1, RBBP4, BRMS1, SIN3A, BRMS1L, C2ORF59 | histone deacetylase |
X(-) | mir-450 | TP53, CUL5, COPS3, GPS1, COPS2, COPS8, COPS6, COPS5, COPS4, COPS7A | cancer suppressor p53 with COP9 signalosome |