Overview of the strategy used to compare GO and the interactome. For a given parent GO term, we extracted the proteins annotated with it and determined their primary distances (shortest path length) in the protein interaction network. The resulting graph was transformed into a dendrogram with UVCLUSTER. We then retrieved the proteins annotated with each child GO term and labeled them in the tree. We finally detected, using the program TreeTracker, the clusters in the tree significantly enriched for each child GO term.