Predictions of the Complete cAMP Model. (A) cAMP synthesis and hydrolysis rates. Glucose is increased to 5 mM at time 60, and increased to 100 mM at time 240. Blue trace: rate of cAMP synthesis. Red trace: rate of cAMP hydrolysis by Pde1. Green trace: rate of cAMP hydrolysis by Pde2. (B) Levels of species in the Gpa2 module. Blue trace: inactive Gpa2. Green trace: active Gpa2. Red trace: Krh. Cyan trace: complex of activated Gpa2 and Krh. (C) Levels of active (blue trace) and inactive (green trace) PKA. (D) Levels of Ras2a and Cdc25 in response to 5 mM glucose at time 60sec, and 100 mM at 240 sec. Top part: Ras2a (blue trace); bottom part: phosphorylated (green trace) and unphosphorylated (blue trace) Cdc25.