Table 4 Parameters of the complete cAMP pathway Model
From: Deterministic mathematical models of the cAMP pathway in Saccharomyces cerevisiae
Parameter name | Value | Units | Source |
|---|---|---|---|
Glucose transport K M | 0.08 | mM | [37] |
Glucose transport V | 1.7 | mmol/s | [37] |
Glucose transport K i | 0.91 | Â | [37] |
Glucose Utilisation k F | 0.03 | l/s | This work |
Gpr1 Glucose association k1 | 0.003 | l2/mmol*s | This work |
Gpr1 Glucose dissociation k1 | 0.14 | l/s | This work |
Gpa2 activation k A | 57682.6 | l2/mmol*s | This work |
Gpa2 deactivation k F | 0.899 | l/s | This work |
Gpa2 deactivation k A | 12989.4 | l2/mmol*s | This work |
Gpa2-Krh association k F | 391089.6 | l2/mmol*s | This work |
Gpa2-Krh dissociation k F | 6.12 | l/s | This work |
Ras2 activation k cat | 0.74 | l/s | This work |
Ras2 activation K M | 1.38 × 10-3 | mmol/l | This work |
Ras2 activation K d | 0.044 | mmol/l | This work |
Ras2 activation a | 32.9 | Â | This work |
Ras2 activation b | 63.8 | Â | This work |
Ras2 deactivation k F | 0.042 | l/s | This work |
Ras2 deactivation k A | 519.8 | l2/mmol*s | This work |
cAMP synthesis k cat Gpa2 | 2933.9 | Â | This work |
cAMP synthesis k cat Ras2 | 650 | Â | This work |
cAMP synthesis K M | 4 × 10-3 | mM | This work |
PKA activation k F | 7.6 × 108 |  | This work |
PKA activation k I | 100 | l/mmol | This work |
PKA deactivation k F | 19.9 | Â | This work |
PKA deactivation k A | 2.2 × 104 | l/mmol | This work |
Cdc25 phosphorylation k cat | 0.18 | l/s | This work |
Cdc25 phosphorylation K M | 5.2 × 10-3 | mmol/l | This work |
Cdc25 dephosphorylation k cat | 2.52 | l/s | This work |
Cdc25 dephosphorylation K M | 1.6 × 10-2 | mmol/l | This work |
Pde1 phosphorylation k cat | 6.82 | l/s | This work |
Pde1 phosphorylation K M | 8.6 × 10-3 | mmol/l | This work |
Pde1 dephosphorylation k cat | 2.4 | l/s | This work |
Pde1 dephosphorylation K M | 1.07 × 10-3 | mmol/l | This work |
cAMP hydrolysis (Pde1) k cat | 1.1 | l/s | This work |
cAMP hydrolysis (Pde1) K M | 0.85 | mmol/l | This work |
cAMP hydrolysis (Pde1p) k cat | 25.25 | l/s | This work |
cAMP hydrolysis (Pde1p)K M | 6 × 10-7 | mmol/l | This work |
cAMP hydrolysis (Pde2)k cat | 1 | l/s | This work |
cAMP hydrolysis (Pde2) K M | 0.002 | mmol/l | [15] |