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Table 4 Parameters of the complete cAMP pathway Model

From: Deterministic mathematical models of the cAMP pathway in Saccharomyces cerevisiae

Parameter name Value Units Source
Glucose transport K M 0.08 mM [37]
Glucose transport V 1.7 mmol/s [37]
Glucose transport K i 0.91   [37]
Glucose Utilisation k F 0.03 l/s This work
Gpr1 Glucose association k1 0.003 l2/mmol*s This work
Gpr1 Glucose dissociation k1 0.14 l/s This work
Gpa2 activation k A 57682.6 l2/mmol*s This work
Gpa2 deactivation k F 0.899 l/s This work
Gpa2 deactivation k A 12989.4 l2/mmol*s This work
Gpa2-Krh association k F 391089.6 l2/mmol*s This work
Gpa2-Krh dissociation k F 6.12 l/s This work
Ras2 activation k cat 0.74 l/s This work
Ras2 activation K M 1.38 × 10-3 mmol/l This work
Ras2 activation K d 0.044 mmol/l This work
Ras2 activation a 32.9   This work
Ras2 activation b 63.8   This work
Ras2 deactivation k F 0.042 l/s This work
Ras2 deactivation k A 519.8 l2/mmol*s This work
cAMP synthesis k cat Gpa2 2933.9   This work
cAMP synthesis k cat Ras2 650   This work
cAMP synthesis K M 4 × 10-3 mM This work
PKA activation k F 7.6 × 108   This work
PKA activation k I 100 l/mmol This work
PKA deactivation k F 19.9   This work
PKA deactivation k A 2.2 × 104 l/mmol This work
Cdc25 phosphorylation k cat 0.18 l/s This work
Cdc25 phosphorylation K M 5.2 × 10-3 mmol/l This work
Cdc25 dephosphorylation k cat 2.52 l/s This work
Cdc25 dephosphorylation K M 1.6 × 10-2 mmol/l This work
Pde1 phosphorylation k cat 6.82 l/s This work
Pde1 phosphorylation K M 8.6 × 10-3 mmol/l This work
Pde1 dephosphorylation k cat 2.4 l/s This work
Pde1 dephosphorylation K M 1.07 × 10-3 mmol/l This work
cAMP hydrolysis (Pde1) k cat 1.1 l/s This work
cAMP hydrolysis (Pde1) K M 0.85 mmol/l This work
cAMP hydrolysis (Pde1p) k cat 25.25 l/s This work
cAMP hydrolysis (Pde1p)K M 6 × 10-7 mmol/l This work
cAMP hydrolysis (Pde2)k cat 1 l/s This work
cAMP hydrolysis (Pde2) K M 0.002 mmol/l [15]