Table 5 Reactions of the Complete cAMP pathway Model
From: Deterministic mathematical models of the cAMP pathway in Saccharomyces cerevisiae
Reaction name | Substrates | Products | Rate law |
|---|---|---|---|
Glucose transport (reversible) | Glucout | Glucin |
|
Glucose metabolism | Glucin | Â | k f [Glucin] |
Gpr1-Glucose Association | Gpr1, Glucout | Gpr1Glucout | k f [Gpr1] [Glucout] |
Gpr1-Glucose dissociation | Gpr1Glucout | Gpr1,Glucout | k f [Gpr1Glucout] |
Gpa2 activation | Gpa2i | Gpa2a | k A [Glucout] [Gpa2i] |
Gpa2 deactivation | Gpa2a | Gpa2i | (k A [Rgs2] + k f ) [Gpa2a] |
Gpa2-Krh association | Gpa2a,Krh | Gpa2aKrh | k f [Gpa2a] [Krh] |
Gpa2-Krh dissociation | Gpa2aKrh | Gpa2a,Krh | k f [Gpa2aKrh] |
Ras2 activation | Ras2i | Ras2a |
|
Ras2 deactivation | Ras2a | Ras2i | (k A [Ira]+k f )·[Ras2a] |
cAMP synthesis | Â | cAMP |
|
PKA activation | PKAi | 2*C |
|
PKA deactivation | 2*C | PKAi | k f [C]2·(1 + (k A [Krh])) |
Cdc25 phosphorylation | Cdc25 | Cdc25P |
|
Cdc25 dephosphorylation | Cdc25P | Cdc25 |
|
Pde1 phosphorylation | Pde1 | Pde1P |
|
Pde1 dephosphorylation | Pde1P | Pde1 |
|
cAMP hydrolysis (Pde1) | cAMP | Â |
|
cAMP hydrolysis (Pde1P) | cAMP | Â |
|
cAMP hydrolysis (Pde2) | cAMP | Â |
|
