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Figure 5 | BMC Systems Biology

Figure 5

From: Mechanism of PP2A-mediated IKKβ dephosphorylation: a systems biological approach

Figure 5

Model parameters are very well identifiable and suggest indirect deactivation of PP2Ac by UVB. (A) The histograms show the parameter values of the best 10% out of 4000 fits. The initial parameter values for these fits were obtained by randomly varying the parameter values of the reference scenario (Table 1) by up to 4 orders of magnitude, as described in the Methods section. (B) The model rejects the hypothesis of immediate UVB induced PP2Ac deactivation. Assuming kdp = 0 in case of UVB stimulation, the experimental data cannot be reproduced (χ2 = 72.05 + 37.78 = 109.83).

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