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Table 1 Model parameters in the reference scenario

From: Mechanism of PP2A-mediated IKKβ dephosphorylation: a systems biological approach

Variable

Process

Value

Unit

ka

association of IL-1 to the receptor

6.7

(μM·s)-1

ki

internalization of the receptor complex

0.0034

s-1

kp

phosphorylation of IKK

0.095

s-1

kdp

dephosphorylation of IKKp

0.00076

s-1

kuv

deactivation of PP2A under UVB

0.00024

s-1

IKKscale

scaling of the model to the data

0.96

-

  1. Note that the unit μM occurs only in the reaction involving IL-1, since all state variables are dimensionless and can be interpreted as fraction of the total initial protein.