TY - JOUR AU - Qin, Huaxia AU - Chan, Michael WY AU - Liyanarachchi, Sandya AU - Balch, Curtis AU - Potter, Dustin AU - Souriraj, Irene J. AU - Cheng, Alfred SL AU - Agosto-Perez, Francisco J. AU - Nikonova, Elena V. AU - Yan, Pearlly S. AU - Lin, Huey-Jen AU - Nephew, Kenneth P. AU - Saltz, Joel H. AU - Showe, Louise C. AU - Huang, Tim HM AU - Davuluri, Ramana V. PY - 2009 DA - 2009/07/17 TI - An integrative ChIP-chip and gene expression profiling to model SMAD regulatory modules JO - BMC Systems Biology SP - 73 VL - 3 IS - 1 AB - The TGF-β/SMAD pathway is part of a broader signaling network in which crosstalk between pathways occurs. While the molecular mechanisms of TGF-β/SMAD signaling pathway have been studied in detail, the global networks downstream of SMAD remain largely unknown. The regulatory effect of SMAD complex likely depends on transcriptional modules, in which the SMAD binding elements and partner transcription factor binding sites (SMAD modules) are present in specific context. SN - 1752-0509 UR - https://doi.org/10.1186/1752-0509-3-73 DO - 10.1186/1752-0509-3-73 ID - Qin2009 ER -