Figure 5From: Exploiting gene deletion fitness effects in yeast to understand the modular architecture of protein complexes under different growth conditionsFitness of the complex core and attachments of single isoforms across different growth conditions. Expected fitness effects upon deletion of a random component of the given core or set of attachment proteins for all 5979 isoforms across the two fermentable and the three non-fermentable media considered. The fitness values are partitioned into four categories: 'strong negative effect' (--/blue), 'moderate negative effect' (-/light-blue), 'weak or no effect' (0/white) and 'positive effect' (+/orange). Each line represents the fitness profile of a given isoform, treating the core and the attachments (att.) separately. 'n/a': the expected fitness effect is unknown due to a lack of quantitative fitness information for the genes in the respective core or attachments. When grouping the fitness profiles, we gave priority to n/a, positive, strong negative and moderate negative fitness effect in that order. Arrows indicate isoform fitness profiles of complexes given as examples in the main text.Back to article page