A possibilistic framework for constraint-based metabolic flux analysis

BMC Systems Biology

Table 1 Features of Possibilistic MFA and alternative approaches

Feature	TMFA	LS-MFA	FS-MFA	Monte Carlo	PMFA
Considers irreversible reaction		x	x	x	x
Usable in scenarios lacking measurements			x	o	x
Includes a check of consistency	x	-	-	o	x
Flexible description of measurements errors			-	x	x
Richer estimations (not only point-wise)			-	x	x
Computational efficiency	x	x	x		x

Possibilistic MFA (PMFA) is compared with four approaches for metabolic flux analysis, Traditional MFA (TMFA), MFA as a constraint least-squares problem (LS-MFA) and the flux spectrum approach (FS-MFA). Legend: (x) provided feature, (-) partially provided feature and (o) potentially provided feature.

ISSN: 1752-0509