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Figure 1 | BMC Systems Biology

Figure 1

From: Reliable transfer of transcriptional gene regulatory networks between taxonomically related organisms

Figure 1

Scheme of the transfer workflow. a, Simplified structure of a typical transcriptional gene regulatory interaction database. Using genetic upstream sequences and transcription factor binding site annotations the TFBSs can be re-adjusted and modeled as PWMs for subsequent TFBS predictions. Sequence clustering tools can be applied to the stored genome annotation and gene/protein sequences to gain information about homologous genes/proteins. b, A regulatory interaction can be transferred from a model organism to a closely related species if the regulator as well as the target gene are orthologous and a matching TFBS can be found in the upstream sequence of the orthologous target gene.

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