Reliable transfer of transcriptional gene regulatory networks between taxonomically related organisms

BMC Systems Biology

Table 1 Comparison of the original and the transferred database content of CoryneRegNet.

	TFs	TFs_C	TFs^K		TFs_C^K	Regulations
CG	128		69			530
			original	transferred	transferred	original	transferred
CD	63	49 (77.8%)	2 (3.2%)	20 (×10)	20 (40.1%)	46	193 (×4.2)
CE	103	77 (74.8%)	5 (4.9%)	28 (×5.6)	28 (36.4%)	64	348 (×5.4)
CJ	55	31 (56.4%)	1 (1.8%)	13 (×13)	13 (41.9%)	51	150 (×2.9)
Av		69.6%	3.3%	x9.5	39.7%		x4.2

Abrev.: CG = The model organism Corynebacterium glutamicum, CD = C. diphtheriae, CE = C. efficiens, CJ = C. jeikeium, Av = Average, TFs = Transcription factors, TFs_C = Common transcription factors with C. glutamicum, TFs^K = Transcription factors with knowledge, TFs_C^K = Transcription factors common with C. glutamicum with knowledge, Regulations = Transcriptional regulatory interactions, original = Original database content, transferred = Database content after network transfer. Percentages/factors: TFs_C = relative to column TFs, TFs^K/original = relative to column TFs, TFs^K/transferred = relative to column TFs^K/orig., TFs_C^K = relative to column TFs_C, Regulations/transferred = relative to column Regulations/original.

ISSN: 1752-0509