Figure 2
From: Knowledge based identification of essential signaling from genome-scale siRNA experiments
The integrated interactome data set is comprised of 16,478 protein interactions, roughly evenly distributed between binding, phosphorylation and expression regulation (left). Phosphorylation and expression regulation interactions (11,017 total) were used to identify enriched gene sets in HeLa and TOV genome wide siRNA screens using PIPA. The edge hits from enriched gene sets (right) are enriched for phosphorylation interactions.