Figure 5
From: Knowledge based identification of essential signaling from genome-scale siRNA experiments
The Cytoskeletal Remodeling: FAK Signaling pathway is enriched for HeLa and TOV edge hits using PIPA but not node hits using HGA enrichment. Red indicators are HeLa siRNA hits and blue indicators are TOV hits. Both HeLa and TOV show significant enrichment of protein interactions connecting hits (p-value = 0.048 and p-value = 0.015 respectively). Different signaling branches in this pathway have lethal effects in the two different cell lines when perturbed, although both branches are annotated as associated with a cell growth phenotype. [GeneGo Metacore (2008)].