NCI60 case study. a) Distribution of the normalized IC50 for three different chemical agents (bars) and the same distribution for all (cell line, drug) pairs (solid line). Δlog10IC50 denotes the log10IC50 change relative to the drug dependent mean over all cell lines. s denotes the standard deviation of Δlog10IC50 over all (cell line, drug) pairs. The dashed line marks the threshold at two standard deviations above the mean. b) The fraction p
of drugs connected to k strains in the NCI60 strain-drug response graph (symbols). The solid line represents the best fit to an exponential decay. c) Graphical representation of the minimal hitting set number 1 in Table 1.