Figure 2

NCI60 case study. a) Distribution of the normalized IC50 for three different chemical agents (bars) and the same distribution for all (cell line, drug) pairs (solid line). Δlog₁₀IC50 denotes the log₁₀IC50 change relative to the drug dependent mean over all cell lines. s denotes the standard deviation of Δlog₁₀IC50 over all (cell line, drug) pairs. The dashed line marks the threshold at two standard deviations above the mean. b) The fraction p _k of drugs connected to k strains in the NCI60 strain-drug response graph (symbols). The solid line represents the best fit to an exponential decay. c) Graphical representation of the minimal hitting set number 1 in Table 1.