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Figure 4 | BMC Systems Biology

Figure 4

From: Visualizing post genomics data-sets on customized pathway maps by ProMeTra – aeration-dependent gene expression and metabolism of Corynebacterium glutamicum as an example

Figure 4

GenomeMap visualization of the transcriptome analysis. Visualization of the transcriptome analysis on a genome map. Presented in rounded rectangles are all 3057 genes of C. glutamicum, arranged in rows starting with dnaA (cg0001) top left, ending with cg3434 down right (A). The presented experimental factors described in the legend of the image (B) are the mean values (M-values) of replicate measurements of the time points T2 to T6 in comparison to the mean values of time point T1. The transcriptome data is represented as five divisions (T2 to T6) of the rectangles. ProMeTra allows to employ different coloring schemes, in this example we have chosen a green to red color mapping for the M-values ranging from 5 to -5. Only those values are displayed that had an error probability less than 5% in a Students t test. Part (A) of the figure gives an overview of the transcriptional regulation on the genomic scale. The original SVG image from ProMeTra can be zoomed to any level of detail and we enlarge the marked region of interest in part (C) of the figure. Here, the two transcriptional units of the nar-operon (transcribed from right to left) and the atp-operon (transcribed from left to right) are presented. For both operons, the genes show a concerted change in regulation at timepoints T4 and T5.

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