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Figure 7 | BMC Systems Biology

Figure 7

From: Specialized or flexible feed-forward loop motifs: a question of topology

Figure 7

Positional effect of the separatrix. Here we illustrate the positional effect of the separatrix S, ξ and ϕX = 0on the functional behaviour of the FFL (a-c). The relative position between the three crossing points with the vertical nullcline = 0 without input determines the functionality of the time course. Positioning shown in (a) results in grader, whereas (b) and (c) display pulser dynamics. The respective relative location is outlined in the boxes. In (d) the unique backbone of parametric requirements defining univocaly the shape of the nullclines is shown. Each column describes the relation (> or <) between two characteristic elements (head column). The single values are described in the text. Column 'Slope' refers to the slope of the nullcline Ż = 0 with input (X > 0) and can be positive or negative. The columns containing '' or '*' do not need to be explicitly addressed, because of parametric inter-dependencies (see text).

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