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Table 1 Dissociation constants between Cks1 and the different subunits.

From: Information theoretical quantification of cooperativity in signalling complexes

Protein or complex

Binding partner

Kd (μM)

Cks1

p27

70

Cks1-Skp2

p27

0.47

Cks1-Cdk2

p27

120

Cks1-Cdk2-Skp2

p27

0.15

Cks1

Skp2

0.014

Cks1-Cdk2

Skp2

0.07

Cks1-p27

Skp2

0.0001

Cks1-Cdk2-p27

Skp2

0.0001

Cks1

Cdk2

1.5

Cks1-Skp2

Cdk2

8

Cks1-p27

Cdk2

3

Cks1-Skp2-p27

Cdk2

2.6

  1. Dissociation constants in bold were derived experimentally. The remaining values were obtained through the thermodynamic cycles [19].