Figure 7

The influence of the parameter values on the calculated dose-response curve. Sensitivity analysis of the calculated relative cell concentration expressed as the ratio of inhibitor-present to inhibitor-free cell concentration of Mycobacterium tuberculosis after an 8-day growth period as a function of 5'-O-(N-salicylsulfamoyl) adenosine (sAMS) concentration. The analysis was performed for the (A) intracellular MbtA-enzyme concentration [E]; (B) apparent reaction rate constant ; (C) upper limit of glycerol uptake rate ; (D) upper limit of glycerol uptake rate ; and (E) time length of cellular growth t, which were each set to its original parameter value (solid line), the value increased by 50% (dashed line), and decreased by 50% (dotted line).