A systems biology framework for modeling metabolic enzyme inhibition of Mycobacterium tuberculosis

BMC Systems Biology

Table 3 Model parameters for cell growth inhibition by sAMS.

Group	Parameter Annotation	Model	Eq.	Source of the value
I	: apparent reaction rate constant	Inhibition Model	15	Set to be 0.7 nM from [53]
	: upper limit of glycerol uptake	Metabolic Network	-	Set to be 1 mmol/(h·gDW) from [42]
	: upper limit of alanine uptake	Metabolic Network	-	Set to be 1 mmol/(h·gDW) from [42]
	t: time length of cellular growth	Population Growth Model	17	Set to be 8 days from [53]
II	[E]: intracellular MbtA concentration	Inhibition Model	15	Obtained by matching experimental data

All parameter values were selected from the literature except for the intracellular MbtA enzyme concentration [E], which was obtained by matching experimental data.

ISSN: 1752-0509