Table 4 Sensitivity coefficients for the parameters in modeling sAMS inhibition.
From: A systems biology framework for modeling metabolic enzyme inhibition of Mycobacterium tuberculosis
Parameter p | Sensitivity Coefficient | ||||
|---|---|---|---|---|---|
|  | 0.1 μM | 1 μM | 10 μM | 100 μM | 500 μM |
| 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 |
| -0.0197 | -0.1966 | -1.9662 | -7.8648 | -7.8648 |
| -0.0067 | -0.0670 | -0.6703 | -2.6812 | -2.6812 |
t | -0.0264 | -0.2636 | -2.6365 | -10.5460 | -10.5460 |
[E] | 0.0264 | 0.2636 | 2.6365 | 0.0000 | 0.0000 |
as a Function of [sAMS]
- The sensitivity coefficient
was calculated from a numerical estimate of 
, where R
C
is the relative cell concentration, defined as the ratio of inhibitor-present to inhibitor-free cell concentrations, and p represents the analyzed parameter.
, where R
C
is the relative cell concentration, defined as the ratio of inhibitor-present to inhibitor-free cell concentrations, and p represents the analyzed parameter.