The capacity for multistability in small gene regulatory networks

BMC Systems Biology

Table 2 Survey of one-component regulatory subnetworks

Subnetwork	Dimer formation	Monomer binding	Dimer binding	Multiple equilibria ruled out?
				IG-T	IG-K	SRG	INJ	CRNT
ab	no	no	no	yes	yes	yes	yes	yes
abcd	no	yes ⁺	no	no	no	no	no	yes
abc	no	yes ^-	no	no	no	no	yes	yes
abe	yes	no	no	no	no	yes	yes	yes
abefg	yes	no	yes ⁺	no	no	no	no	no
abef	yes	no	yes ^-	no	no	no	yes	yes
abcde	yes	yes ⁺	no	no	no	no	no	yes
abcdefg	yes	yes ⁺	yes ⁺	no	no	no	no	no
abcdef	yes	yes ⁺	yes ^-	no	no	no	no	yes
abce	yes	yes ^-	no	no	no	no	yes	yes
abcef	yes	yes ^-	yes ^-	no	no	no	yes	yes
abcefg	yes	yes ^-	yes ⁺	no	no	no	no	no

Analysis of twelve gene regulatory subnetworks that consist of one gene and one gene product. The letters that make up the Subnetwork names refer to the constituent reactions listed in Table 1. The entries yes^+/- indicate productive/unproductive binding to the gene promoter. The five analytical tools IG-T, IG-K, SRG, INJ, and CRNT are described in the text. In the three cases where multiple equilibria were not ruled out (subnetworks abefg, abcdefg, and abcefg), the CRNT provided example sets of rate constants leading to bistability.

ISSN: 1752-0509