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Table 1 Overall view of tested hepatocyte apoptosis models

From: Modeling system states in liver cells: Survival, apoptosis and their modifications in response to viral infection

Model Description Nodes Edges Steady States Feedback Loops State
Model A (All) All interactions and crosstalk possibilities considered. These include:
additional component as a pos. feedback between Akt/PKB and PI3K, additional component as a pos. feedback between Bcl-2/xL and Stat3, additional Akt substrates
74 108 4 2 positive feedback loops Apoptosis
Survival
Apoptosis
Survival
Model 1 reduced core model (only components listed in official databases) 66 94 1 no feedback loop Apoptosis
Model 2 Core model + ILK pathway and Akt/PKB* 68 100 2 1 positive feedback loop Apoptosis
Survival
Model 3 Core model + TRADD/FADD interactions and ILK pathway 68 100 1 no feedback loop Apoptosis
Model 4 Core model + Akt/PKB* and PI3K pathway 68 100 2 1 positive feedback loop Apoptosis
Survival
Model C (Core) Core model 67 99 1 no feedback loop Apoptosis
Model 5 Model All with a Bid KO 74 107 4 2 positive feedback loops Apoptosis
Survival
Apoptosis
Survival
Model 6 Model All + cytomegalovirus infection (influence of M45) 75 110 4 2 positive feedback loops Apoptosis
Survival
Apoptosis
Survival
Model 7 Model All + cytomegalovirus infection (influence of M36) 75 110 4 2 positive feedback loops Apoptosis
Survival
Apoptosis
Survival
Model 8 Model All + cytomegalovirus infection (influence of M36 and M45) 76 111 4 2 positive feedback loops Apoptosis
Survival
Apoptosis
Survival
  1. 1Further models tested in detail; additional feedback/forward loops to the core model C: These are all included in model A. Modifications for Model C to get Model A: additional nodes: Akt*, Collagen, Integrin, M45, DAXX, ask1, MKK4, MEKK1, mTor, RIP*, Bcl-2/xL*; removal of the following nodes: Bak/Bax, CytC