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Table 2 Steady state analysis for hepatocyte apoptosis Model A (complete model)1

From: Modeling system states in liver cells: Survival, apoptosis and their modifications in response to viral infection

Model A
Steady State A1
Value Model A
Steady State A2
Value Model A
Steady State A3
Value Model A
Steady State A4
Value
Akt* 0 Akt* 0 Akt* 0,99 Akt* 0,99
Akt/PKB 0 Akt/PKB 0 Akt/PKB 0,79 Akt/PKB 0,79
Apaf1 1 Apaf1 0 Apaf1 0 Apaf1 0
Apoptosis 0,98 Apoptosis 0,98 Apoptosis 0 Apoptosis 0
Bcl-2/Xl 0 Bcl-2/Xl 1 Bcl-2/Xl 0 Bcl-2/Xl 1
Bcl-2/Xl* 0 Bcl-2/Xl* 1 Bcl-2/Xl* 0 Bcl-2/Xl* 1
Caspase-10 0,85 Caspase-10 0,85 Caspase-10 0 Caspase-10 0
Caspase-3 0,99 Caspase-3 0,95 Caspase-3 0 Caspase-3 0
Caspase-6 1 Caspase-6 1 Caspase-6 0 Caspase-6 0
Caspase-7 1 Caspase-7 0,83 Caspase-7 0 Caspase-7 0
Caspase-8 0,78 Caspase-8 0,78 Caspase-8 0 Caspase-8 0
Caspase-9 1 Caspase-9 0 Caspase-9 0 Caspase-9 0
Cleavage 1 Cleavage 1 Cleavage 0 Cleavage 0
CytC 1 CytC 0 CytC 0 CytC 0
DFF40 1 DFF40 1 DFF40 0 DFF40 0
DFF45 1 DFF45 1 DFF45 0 DFF45 0
Fragmentation 0,85 Fragmentation 0,85 Fragmentation 0 Fragmentation 0
Survival Genes 0 Survival Genes 0 Survival Genes 0,99 Survival Genes 0,99
Degradation 0,93 Degradation 0,93 Degradation 0,9 Degradation 0,9
Caspase 1 Caspase 1 Caspase 0,01 Caspase 0,01
IKK 0 IKK 0 IKK 0,93 IKK 0,93
IkBa 0 IkBa 0 IkBa 0,91 IkBa 0,91
NFkB 0 NFkB 0 NFkB 0,79 NFkB 0,79
PI3K 0 PI3K 0 PI3K 0,73 PI3K 0,73
Stat3 0 Stat3 0,93 Stat3 0 Stat3 0,93
Survival 0 Survival 0 Survival 0,93 Survival 0,93
mTor 0 mTor 0 mTor 1 mTor 1
s69 0 s69 0 s69 1 s69 1
tBid 0,98 tBid 0,98 tBid 0 tBid 0
  1. 1All key nodes of the network are listed together with the activation state for each steady state.