Table 2 Steady state analysis for hepatocyte apoptosis Model A (complete model)1
Model A Steady State A1 | Value | Model A Steady State A2 | Value | Model A Steady State A3 | Value | Model A Steady State A4 | Value |
|---|---|---|---|---|---|---|---|
Akt* | 0 | Akt* | 0 | Akt* | 0,99 | Akt* | 0,99 |
Akt/PKB | 0 | Akt/PKB | 0 | Akt/PKB | 0,79 | Akt/PKB | 0,79 |
Apaf1 | 1 | Apaf1 | 0 | Apaf1 | 0 | Apaf1 | 0 |
Apoptosis | 0,98 | Apoptosis | 0,98 | Apoptosis | 0 | Apoptosis | 0 |
Bcl-2/Xl | 0 | Bcl-2/Xl | 1 | Bcl-2/Xl | 0 | Bcl-2/Xl | 1 |
Bcl-2/Xl* | 0 | Bcl-2/Xl* | 1 | Bcl-2/Xl* | 0 | Bcl-2/Xl* | 1 |
Caspase-10 | 0,85 | Caspase-10 | 0,85 | Caspase-10 | 0 | Caspase-10 | 0 |
Caspase-3 | 0,99 | Caspase-3 | 0,95 | Caspase-3 | 0 | Caspase-3 | 0 |
Caspase-6 | 1 | Caspase-6 | 1 | Caspase-6 | 0 | Caspase-6 | 0 |
Caspase-7 | 1 | Caspase-7 | 0,83 | Caspase-7 | 0 | Caspase-7 | 0 |
Caspase-8 | 0,78 | Caspase-8 | 0,78 | Caspase-8 | 0 | Caspase-8 | 0 |
Caspase-9 | 1 | Caspase-9 | 0 | Caspase-9 | 0 | Caspase-9 | 0 |
Cleavage | 1 | Cleavage | 1 | Cleavage | 0 | Cleavage | 0 |
CytC | 1 | CytC | 0 | CytC | 0 | CytC | 0 |
DFF40 | 1 | DFF40 | 1 | DFF40 | 0 | DFF40 | 0 |
DFF45 | 1 | DFF45 | 1 | DFF45 | 0 | DFF45 | 0 |
Fragmentation | 0,85 | Fragmentation | 0,85 | Fragmentation | 0 | Fragmentation | 0 |
Survival Genes | 0 | Survival Genes | 0 | Survival Genes | 0,99 | Survival Genes | 0,99 |
Degradation | 0,93 | Degradation | 0,93 | Degradation | 0,9 | Degradation | 0,9 |
Caspase | 1 | Caspase | 1 | Caspase | 0,01 | Caspase | 0,01 |
IKK | 0 | IKK | 0 | IKK | 0,93 | IKK | 0,93 |
IkBa | 0 | IkBa | 0 | IkBa | 0,91 | IkBa | 0,91 |
NFkB | 0 | NFkB | 0 | NFkB | 0,79 | NFkB | 0,79 |
PI3K | 0 | PI3K | 0 | PI3K | 0,73 | PI3K | 0,73 |
Stat3 | 0 | Stat3 | 0,93 | Stat3 | 0 | Stat3 | 0,93 |
Survival | 0 | Survival | 0 | Survival | 0,93 | Survival | 0,93 |
mTor | 0 | mTor | 0 | mTor | 1 | mTor | 1 |
s69 | 0 | s69 | 0 | s69 | 1 | s69 | 1 |
tBid | 0,98 | tBid | 0,98 | tBid | 0 | tBid | 0 |