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Table 1 Best fit parameter set for ligand L144.

From: Transforming Boolean models to continuous models: methodology and application to T-cell receptor signaling

Species Input n k Input n k Input n k τ
zap70 tcrphosp 2 0.29 lck 1 0.33 ccbl 1 0.30 2.77
tcrphosp tcr 1 0.34 lck 1 0.34 fyn 1 0.13 0.03
tcr TCRlig 1 0.20 ccbl 1 0.41     0.59
slp76 gads 1 0.35        0.24
sek pkcth 1 0.26        0.01
rsk erk 3 0.30        1.00
rlk lck 1 0.36        1.02
rasgrp pkcth 1 0.40 dag 1 0.39     2.76
ras rasgrp 3 0.33 grb2sos 17 0.39     7.50
raf ras 3 0.31        11.80
plcgbind lat 5 0.36        0.01
plcgact zap70 1 0.10 slp76 1 0.29 rlk 1 0.24 0.01
  plcgbind 1 0.31 itk 2 0.34     
pkcth dag 2 0.31        8.66
pagcsk tcr 1 0.32 fyn 1 0.69     1.33
nfkb ikb 3 0.30        1.00
nfat calcen 1 0.37        5.03
mek raf 1 0.28        0.01
TCRlig ext. sig. 1 0.12        1.28
lck pagcsk 2 0.30 cd4 2 0.37 cd45 1 0.33 0.15
lat zap70 3 0.14        0.01
jun jnk 3 0.30        1.00
jnk sek 4 0.57        0.08
itk zap70 2 0.10 slp76 1 0.31     0.01
ip3 plcgact 2 0.38        0.01
ikkbeta pkcth 18 0.33        10.55
ikb ikkbeta 3 0.30        1.00
grb2sos lat 8 0.46        5.26
gads lat 1 0.36        0.12
fyn tcr 6 0.27 lck 2 0.30 cd45 4 0.37 0.46
fos erk 3 0.30        1.00
erk mek 2 0.28        0.10
dag plcgact 3 0.28        0.01
creb rsk 3 0.30        1.00
cre creb 3 0.30        1.00
cd4 ext. sig. 1 0.32        2.25
cd45 ext. sig. 1 0.35        1.64
ccbl zap70 1 0.70        0.29
calcen ca 11 0.30        4.53
ca ip3 3 0.33        0.20
ap1 jun 3 0.30 fos 3 0.30     1.00
  1. The bold entries are the parameters downstream of all measured species. They were not affected by the optimization process.