Table 4 Pathways enriched among the targets of 3 core miRNAs
From: A Novel microRNA and transcription factor mediated regulatory network in schizophrenia
miRNA | Enriched pathway of miRNA targetsa | p-value |
|---|---|---|
hsa-miR-195 | TGF-β signaling | 3.98 × 10-5 |
|  | Axonal guidance signaling | 1.35 × 10-4 |
|  | Wnt/β-catenin signaling | 2.04 × 10-4 |
|  | BMP signaling pathway | 3.47 × 10-4 |
|  | FGF signaling | 7.59 × 10-4 |
|  | Protein ubiquitination pathway | 9.12 × 10-4 |
|  | CDK5 signaling | 1.55 × 10-3 |
|  | PTEN signaling | 1.86 × 10-3 |
|  | Amyloid processing | 2.00 × 10-3 |
|  | B cell receptor signaling | 3.72 × 10-3 |
|  | Inositol phosphate metabolism | 4.57 × 10-3 |
|  | PI3K/AKT signaling | 4.79 × 10-3 |
|  | Reelin signaling in neurons | 4.79 × 10-3 |
|  | Synaptic long term potentiation | 7.08 × 10-3 |
|  | PPARα/RXRα activation | 7.59 × 10-3 |
|  | Ephrin receptor signaling | 7.59 × 10-3 |
|  | Insulin receptor signaling | 9.12 × 10-3 |
hsa-miR-20b | Cell cycle: G1/S checkpoint regulation | 1.10 × 10-4 |
|  | Reelin signaling in neurons | 2.75 × 10-4 |
|  | B cell receptor signaling | 3.55 × 10-4 |
|  | Axonal guidance signaling | 4.17 × 10-4 |
|  | TGF-β signaling | 5.50 × 10-4 |
|  | p53 signaling | 1.12 × 10-3 |
|  | Semaphorin signaling in neurons | 1.29 × 10-3 |
|  | SAPK/JNK signaling | 1.35 × 10-3 |
|  | Hypoxia signaling in the cardiovascular system | 2.04 × 10-3 |
|  | Wnt/β-catenin signaling | 3.24 × 10-3 |
|  | PI3K/AKT signaling | 3.89 × 10-3 |
|  | CNTF signaling | 3.98 × 10-3 |
|  | Cell cycle: G2/M DNA damage checkpoint regulation | 5.75 × 10-3 |
|  | Circadian rhythm signaling | 6.03 × 10-3 |
|  | Ephrin receptor signaling | 6.03 × 10-3 |
|  | Factors promoting cardiogenesis in vertebrates | 7.41 × 10-3 |
|  | FGF signaling | 7.41 × 10-3 |
|  | HIF1α signaling | 7.59 × 10-3 |
|  | ERK/MAPK signaling | 8.71 × 10-3 |
hsa-miR-9-3 | ERK/MAPK signaling | 1.58 × 10-4 |
|  | Regulation of actin-based motility by Rho | 2.88 × 10-3 |
|  | Clathrin-mediated endocytosis | 3.72 × 10-3 |
|  | Axonal guidance signaling | 3.89 × 10-3 |
|  | Ephrin receptor signaling | 4.17 × 10-3 |
|  | Fcγ receptor-mediated phagocytosis in macrophages and monocytes | 6.31 × 10-3 |