Local entropy better characterises the metastatic network. A) For each of the four breast cancer cohorts, we count the number of genes showing increases (grey) and decreases (black) in local entropy (S), negative local mean correlation (D), and heterogeneity (negative local mean absolute correlation) H in the metastatic PIN-mRNA networks. In all cases, nodes of degree ≥ 10 were selected. B) Corresponding -log10(p-values) from a one-tailed binomial test. The line -log10(0.05) is shown in green.