Increased entropy of signal transduction in the cancer metastasis phenotype

BMC Systems Biology

Table 2 Gene Set Enrichment Analysis of the top 200 genes of which 133 showed increases in entropy.

Pathway	P (dS > 0)	P(dS < 0)	Example genes
Apoptosis	6e-7	n.s	FAS, TP53, TP53BP2, BCL2, BCL2L1, CASP3
IL2	6e-4	n.s	IL2RB, HRAS, FOS, SOS1, LCH, SHC1
AR	8e-4	n.s	SNX1, RBX1, BSG, NOTCH1, RAB27A, TAF9
IGF1	9e-4	n.s	IGF1, IRS1, IGFBP7

While we observed enrichment of biological pathways among genes showing increases in entropy, there was none among the 67 genes showing decreases. P-values of enrichment (one tailed Fisher's exact test) against genes showing entropy increases (dS > 0) and decreases are given (dS < 0) and were calculated using all nodes of degree ≥ 10 as reference (1903 genes) to avoid intrinsic literature bias. n.s = not significant

ISSN: 1752-0509