Coregulation of regulatory and CTR genes. A correlation matrix was generated for the 146 regulatory genes and 399 genes present in the CTR by using the Hamming distance. Based on previous experimental results, we used 60% agreement as a cut-off to identify coregulation. Using this criterion, we could identify 25 regulatory genes (red solid dots) that were coregulated with 85% of the genes present in the CTR (black solid dots). The relevant similarity measurement values are provided in the additional file 5.