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Table 2 Parameters for Intracellular Gene Network of Epidermal Model

From: Integrative multicellular biological modeling: a case study of 3D epidermal development using GPU algorithms

Parameter Value Description
ka 0.0003 Notch (N)/Delta (D) binding rate
kd 0.12 Bound complex (B) unbinding rate
dB 0.19 Bound complex (B) decay rate
aBN 0.01 Bound complex (B) regulation of Notch (N)
bBN 1 Bound complex (B) regulation of Notch (N)
cBN 1 Bound complex (B) regulation of Notch (N)
hBN -2 Bound complex (B) regulation of Notch (N)
bON 1 Ovol2 (O2) regulation of Notch (N)
cON 0.5 Ovol2 (O2) regulation of Notch (N)
hON 2 Ovol2 (O2) regulation of Notch (N)
dN 0.03 Notch (N) decay rate
aND 0.01 Notch (N) regulation of Delta (D)
bND 1 Notch (N) regulation of Delta (D)
cND 10 Notch (N) regulation of Delta (D)
hND 2 Notch (N) regulation of Delta (D)
dD 0.006 Delta (D) decay rate
aVO 0.1 Ovol1 (O1) regulation of Ovol2 (O2)
bVO 2 Ovol1 (O1) regulation of Ovol2 (O2)
cVO 1 Ovol1 (O1) regulation of Ovol2 (O2)
hVO 2 Ovol1 (O1) regulation of Ovol2 (O2)
bGO 1 TGF-β (G) regulation of Ovol2 (O2)
cGO 1 TGF-β (G) regulation of Ovol2 (O2)
hGO 1 TGF-β (G) regulation of Ovol2 (O2)
dO 1 Ovol2 (O2) decay rate
bOV 2 Ovol2 (O2) regulation of Ovol1 (O1)
cOV 1 Ovol2 (O2) regulation of Ovol1 (O1)
hOV 2 Ovol2 (O2) regulation of Ovol1 (O1)
bAV 1 Basement adhesion (A) regulation of Ovol1 (O1)
cAV 1 Basement adhesion (A) regulation of Ovol1 (O1)
hAV 1 Basement adhesion (A) regulation of Ovol1 (O1)
dV 1 Ovol1 (O1) decay rate
aOM 0.1 Ovol2 (O2) regulation of c-Myc (M)
bOM 1 Ovol2 (O2) regulation of c-Myc (M)
cOM 1 Ovol2 (O2) regulation of c-Myc (M)
hOM 1 Ovol2 (O2) regulation of c-Myc (M)
dM 1 c-Myc (M) decay rate