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Table 1 Comparison of predicted in silico virulence with experimentally determined in vivo virulence

From: Systems approach to investigating host-pathogen interactions in infections with the biothreat agent Francisella. Constraints-based model of Francisella tularensis

LVS locus Schu4 locus Gene Virulence
    in silico in vivo
FTL_1071 FTT_1019c guaA + +
FTL_1478 FTT_1317c guaB + +
FTL_0395 FTT_0893 purM + +
FTL_0396 FTT_0894 purCD + +
FTL_1504 FTT_0721c katG - +
FTL_1791 FTT_0068 sodB - +
FTL_0483 FTT_0413c glgB - +
FTL_1262 FTT_0945   + +
FTL_0838 FTT_1124 metN + +
FTL_0837 FTT_1125 metIQ + +
FTL_0789 FTT_1165c aspC2 - +
FTL_0606 FTT_1450 wbtM - +
FTL_0594 FTT_1462c wbtC - +
FTL_0592 FTT_1464c wbtA - +
FTL_0304 FTT_1490   - +
FTL_1701 FTT_1631c gplX - +
FTL_0058 FTT_1168   + +
  1. Accuracy of iRS635 virulence prediction = 47%