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Table 2 Metabolite exchanges between parasite and host: prediction vs. experiment

From: Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis

Metabolite Predicted Experiment Comment References
Glucose Uptake uptake   [57, 128, 129]
Lactate Secretion secretion   [57, 128, 129]
Hemoglobin uptake uptake   [57, 128]
Amino acids Secretion secretion   [57, 128, 129]
Isoleucine uptake uptake   [57, 128, 129]
Nucleosides/nucleobases uptake uptake   [128–130]
Choline uptake uptake   [68, 128, 129, 131]
Ethanolamine almost no exchange uptake No gene assigned to ethanolamine transporter [128, 132]
Phosphatidylethanolamine uptake uptake   [128, 132]
Phosphatidylserine uptake uptake   [128]
Phosphate uptake uptake   [64, 128, 129]
Pantothenate uptake uptake   [62, 128, 129]
Nicotinamide/nicotinate uptake uptake   [43, 128]
Folate uptake uptake   [128, 129]
4-aminobenzoic acid uptake uptake   [128, 129]
ADP uptake/secretion uptake secretion in early blood stage when ATP can still be salvaged from host [65, 128, 129]
ATP uptake/secretion secretion uptake in early blood stage when host glycolysis is not repressed yet [65, 128, 129]
Glycerol uptake/secretion uptake/secretion   [128, 129]
Glutathione conjugate secretion secretion   [63, 128, 129]
Ornithine mostly secretion secretion   [43]
Cholesterol uptake uptake   [128]
Formate no exchange secretion Erythrocyte lacks reactions and transport processes to dispose of metabolite [128, 129]
Fe2+ no exchange/uptake uptake   [128, 129]
H+ Mostly secretion secretion   [128, 129]
HC03- no exchange secretion Erythrocyte lacks reactions and transport processes to dispose of metabolite [128, 129]
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BMC Systems Biology

ISSN: 1752-0509

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