|
1.1.1.205
|
IMP dehydrogenase
|
Yes
|
No
|
Precursor import (adenosine, hypoxanthine, inosine)
|
[133]
|
|
1.1.1.267
|
1-deoxy-D-xylulose-5-phosphate reducetoisomerase
|
Yes
|
Yes
| |
[84]
|
|
1.3.1.9
|
enoyl-ACP-reductase
|
Yes
|
Yes
| |
[134–136]
|
|
1.3.3.1
|
Dihydroorotate oxidase
|
No
|
Yes
| |
[92–95, 137]
|
|
1.3.99.1
|
Succinate dehydrogenase
|
No
|
No
|
Presumably unspecific off-target effects
|
[75]
|
|
1.5.1.3
|
Dihydrofolate reductase
|
No
|
No
|
Necessary to block all reactions catalyzed by the enzyme
|
[138–140]
|
|
1.6.5.3
|
NADH dehydrogenase (ubiquinone)
|
No
|
No
|
Presumably unspecific off-target effects
|
[74]
|
|
1.8.1.7
|
glutathione reductase
|
Yes
|
Yes
| |
[141, 142]
|
|
1.8.1.9
|
thioredoxin reductase
|
Yes
|
Yes
| |
[143, 144]
|
|
1.10.2.2
|
cytochrome c reductase
|
Yes
|
Yes
| |
[145]
|
|
1.15.1.1
|
superoxide dismutase
|
Yes
|
Yes
| |
[146]
|
|
1.17.4.1
|
Ribonucleoside-diphosphate reductase
|
No
|
Yes
| |
[147–149]
|
|
2.1.1.100
|
Protein-S-isoprenylcysteine-O-methyltransferase
|
Yes
|
Yes
| |
[150, 151]
|
|
2.1.1.103
|
Phosphoethanolamine methyltrans-ferase
|
Yes
|
No
|
Presumably unspecific off-target effects
|
[77, 79]
|
|
2.1.1.45
|
Thymidylate synthase
|
No
|
Yes
| |
[152, 153]
|
|
2.1.1.64
|
3-Demethylubiquinone-9,3-O-methyltransferase
|
Yes
|
Yes
| |
[154]
|
|
2.3.1.24
|
sphingosine-N-acyltransferase
|
Yes
|
Yes
| |
[155]
|
|
2.3.1.37
|
delta-aminolevulinate synthase
|
Yes
|
Yes
| |
[99, 101]
|
|
2.3.1.41
|
3-Oxoacyl-[acyl-carrier protein] synthase
|
Yes
|
Yes
| |
[156, 157]
|
|
2.3.1.50
|
serine-palmitoyl transferase
|
No
|
Yes
| |
[155]
|
|
2.4.2.1
|
Purine-nucleoside phosphorylase
|
Yes
|
No
|
Precursor import (hypoxanthine, xanthine)
|
[158]
|
|
2.4.2.8
|
Hypoxanthine phosphoribosyltransferase
|
Yes
|
No
|
Necessary to block all reactions catalyzed by the enzyme
|
[159–161]
|
|
2.5.1.15
|
Dihydropteroate synthase
|
Yes
|
No
|
Precursor import (folate)
|
[162–164]
|
|
2.5.1.16
|
Spermidine synthase
|
Yes
|
No
|
Precursor import (spermidine)
|
[165]
|
|
2.5.1.18
|
Glutathione transferase
|
Yes
|
Yes
| |
[166–169]
|
|
2.5.1.19
|
3-Phosphoshikimate 1- carboxyvinyltransferase
|
Yes
|
No
|
Precursor import (4-aminobenzoate, folate)
|
[170]
|
|
2.5.1.58
|
Farnesyl-diphosphate Farnesyltransferase
|
No
|
Yes
| |
[171]
|
|
2.7.1.32
|
Choline kinase
|
No
|
No
|
Presumably unspecific off-target effects
|
[78]
|
|
2.7.8.3
|
Ceramide-cholinephosphotransferase
|
Yes
|
Yes
| |
[155]
|
|
3.3.1.1
|
S-adenosyl-l-homocysteine hydrolase
|
Yes
|
Yes
| |
[172–175]
|
|
3.4.11.1
|
leucine aminopeptidase
|
Yes
|
No
|
Precursor import (amino acids)
|
[176]
|
|
3.4.14.1
|
dipeptidyl aminopeptidase 1
|
No
|
No
|
Precursor import (amino acids)
|
[177]
|
|
3.4.23.38
|
plasmepsins (aspartic acid proteases)
|
No
|
No
|
Precursor import (amino acids)
|
[178, 179]
|
|
3.4.23.39
|
plasmepsins (aspartic acid proteases)
|
No
|
No
|
Precursor import (amino acids)
|
[178, 179]
|
|
3.5.1.89
|
N-acetyl glucosaminylphosphatidyli-nositol deacetylase
|
No
|
Yes
| |
[180]
|
|
3.5.2.3
|
dihydroorotase
|
Yes
|
Yes
| |
[96, 137]
|
|
3.5.4.4
|
Adenosine deaminase
|
Yes
|
No
|
Precursor import (hypoxanthine, inosine, xanthine)
|
[181, 182]
|
|
4.1.1.17
|
Ornithine decarboxylase
|
No
|
No
|
Precursor import (spermidine, putrescine); alternative reaction R01152
|
[183–185]
|
|
4.1.1.23
|
Orotidine-5'-phosphate decarboxylase
|
Yes
|
Yes
| |
[89–91, 97, 98]
|
|
4.1.1.50
|
Adenosylmethionine decarboxylase
|
No
|
No
|
Precursor import (spermidine)
|
[186]
|
|
4.1.2.13
|
Fructose-bisphosphate aldolase
|
Yes
|
No
|
Presumable main antimalarial effect is impaired host cell invasion
|
[187, 188]
|
|
4.2.1.1
|
carbonic anhydrase
|
Yes
|
Yes
| |
[87]
|
|
4.2.1.24
|
Delta-aminolevulinic acid dehydratase
|
No
|
Yes
| |
[100]
|
|
4.2.1.58-61
|
3-hydroxyacyl-ACP dehydratase
|
Yes
|
Yes
| |
[189]
|
|
4.2.3.5
|
Chorismate synthase
|
Yes
|
No
|
Precursor import (4-aminobenzoate, folate)
|
[92]
|
|
4.4.1.5
|
Lactoylglutathione lyase
|
Yes
|
Yes
| |
[190]
|
|
4.6.1.12
|
2-C-methyl-D-erythritol-2,4- Cyclodiphosphate-synthase
|
No
|
Yes
| |
[86]
|
|
5.99.1.2
|
topoisomerase I
|
Yes
|
Yes
| |
[191]
|
|
5.99.1.3
|
topoisomerase II
|
Yes
|
Yes
| |
[192–194]
|
|
6.1.1.3
|
Threonine-tRNA ligase
|
Yes
|
Yes
| |
[195]
|
|
6.1.1.7
|
Alanine-tRNA ligase
|
Yes
|
Yes
| |
[196]
|
|
6.3.2.2
|
Gamma-glutamylcysteine synthetase
|
Yes
|
Yes
| |
[144, 197, 198]
|
|
6.3.4.4
|
Adenylosuccinate synthetase
|
Yes
|
Yes
| |
[199]
|
|
6.3.5.2
|
GMP synthetase
|
No
|
No
|
Necessary to block all reactions catalyzed by the enzyme; precursor import(guanine/guanosine)
|
[200]
|
|
6.3.5.5
|
Carbamoyl-phosphate synthase (glutamine-hydrolysing)
|
No
|
Yes
| |
[88]
|
|
6.3.5.8
|
amino-deoxychorismate synthase
|
No
|
No
|
Precursor import (4-aminobenzoate, folate)
|
[128]
|
|
6.4.1.2
|
Acetyl-CoA carboxylase
|
Yes
|
Yes
| |
[156]
|
