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Table 4 Top ranking predicted essential reactions

From: Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis

Enzyme name Compartment Pathway EC Super-Target Score
adenylate cyclase apicoplast Purine metabolism 4.6.1.1 x 4
fumarase cytosol Citrate cycle 4.2.1.2 x 4
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase apicoplast Biosynthesis of isopentenyl diphosphate 2.7.7.60 x 4
4-hydroxy-3-methylbut-2-enoyl-diphosphate synthase apicoplast Biosynthesis of isopentenyl diphosphate 1.17.4.3   3
CDP-ME kinase apicoplast Biosynthesis of isopentenyl diphosphate 2.7.1.148   3
pantetheine-phosphate adenylyltransferase cytosol CoA biosynthesis 2.7.7.3   3
pyridoxal 5-phosphate synthase cytosol Vitamin B6 metabolism    3
amino acid transporter Cytosol ↔ apicoplast Transport    3
geranyl-diphosphate synthase cytosol Terpenoid biosynthesis 2.5.1.1 x 2
farnesyl-diphosphate synthase cytosol Terpenoid biosynthesis 2.5.1.10 x 2
2-Octaprenylphenol hydroxylase mitochondrion Ubiquinone biosynthesis 1.14.13.- x 2
ubiquinone biosynthesis methyltransferase mitochondrion Ubiquinone biosynthesis 2.1.1.- x 2
uroporphyrinogen decarboxylase apicoplast Porphyrin metabolism 4.1.1.37 x 2
coproporphyrinogen oxidase apicoplast Porphyrin metabolism 1.3.3.3 x 2
UMP-CMP kinase apicoplast Pyrimidine metabolism 2.7.4.14 x 2
aspartate carbamoyltransferase cytosol Pyrimidine metabolism 2.1.3.2 x 2
orotate phosphoribosyltransferase cytosol Pyrimidine metabolism 2.4.2.10 x 2
cysteine desulfurase apicoplast/mitochondrion Fe-S-protein biogenesis 2.8.1.7 x 2
tRNA ligase (Ile, Lys, Met, Trp, Tyr) cytosol/apicoplast/mitochondrion Aminoacyl-tRNA biosynthesis 6.1.1.1/6.1.1.2/6.1.1.5/6.1.1.6/6.1.1.10 x 2
glutathione synthase cytosol Glutathione metabolism 6.3.2.3 x 2
riboflavin kinase cytosol Riboflavin metabolism 2.7.1.26 x 2
glucosamine 6-phosphate synthase apicoplast Aminosugars metabolism 2.6.1.16 x 2
mannose-6-phosphate isomerase cytosol Fructose and mannose metabolism 5.3.1.8 x 2
cytochrome-c oxidase mitochondrion Oxidative phosphorylation 1.9.3.1 x 2
choline-phosphate cytidylyltransferase cytosol Glycerophospholipid metabolism 2.7.7.15 x 2
deoxyhypusine synthase cytosol Activation of eiF5A 2.5.1.46 x 2