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Table 2 Cliques of Dtwith corresponding p-values for the ERBB pathway

From: Gene set analysis exploiting the topology of a pathway

  H0: Σ1= Σ2 H0: μ1= μ2
Clique p-value p-value
(EGFR, EGF, TGFA, AR, BTC, EPR) 0.245 0.147
(EGFR, PLCG) 0.233 0.006
(EGFR, Cbl) 0.004 0.007
(EGFR, STAT5) 0.141 0.318
(EGFR, Src) 0.224 0.176
(EGFR, Crk) 0.047 0.196
(EGFR, Nck, Grb2) 0.018 0.104
(EGFR, Shc, Grb2) 0.390 0.159
(Sos, Grb2, Ras) 0.031 0.145
(Ras, MEK, Raf) 0.022 0.030
(Ras, MEK, JNKK) 0.004 0.694
(Ras, Grb2, JNKK) 0.048 0.757
(MEK, JNK, JNKK) 0.009 0.186
(MEK, JNK, ERK) 0.678 0.075
(ERK, JNK, Elk) 0.125 0.242
(ERK, Myc) 0.515 0.101
(Src, FAK) 0.421 0.524
(Crk, Abl) 0.000 0.135
(PAK, Nck, JNKK) 0.004 0.099
(JNKK, Nck, Grb2) 0.011 0.190
(JNK, Jun) 0.559 0.033
(PLCG, CAMK) 0.930 0.012
(PLCG, PKC) 0.127 0.048
  1. Cliques of the triangulated graph Dt with corresponding p-values for the ERBB pathway. The first column p-values refers to the test (1), the second one to the test (2). The p-values in italics in the second column are exact, i.e., are computed on the exact null distribution of the test statistics.