Giant component of the human disease map. The giant component of the disease map comprised 123 disease nodes (yellow, orange, red, and purple nodes) arranged in three subregions. Some disease names are highlighted. The top region (yellow and orange nodes) contains muscular, cardiovascular and metabolic disorders as well as parathyroid neoplasms and pituitary neoplasms. The middle region is made up of hematological malignancies (red nodes) and immune system-related pathologies such as multiple sclerosis, acquired immunodeficiency syndrome, and rheumatoid arthritis (purple nodes), whereas non-hematological malignancies are located in the lower region (orange nodes).