Figure 2
From: A yeast's eye view of mammalian reproduction: cross-species gene co-expression in meiotic prophase
The framework to derive conserved co-expression networks for meiotic prophase. Three types of metagenes were compiled: YMH represents genes conserved among yeast, mice, and humans; YM represents genes conserved between yeast and mice; YH represents genes conserved between yeast and humans. Time-series microarray profiles for meiotic prophase are available from yeast (Y), mouse postnatal testis (Mm), mouse embryonic ovary (Mf), and human fetal ovary (Hf). Gene co-expression networks were constructed by including metagene pairs showing co-expression across species. The network Y-M m was constructed using metagenes YMH and YM, and microarrays Y and Mm. The network Y-M f was constructed using metagenes YMH and YM, and microarrays Y and Mf. The network Y-H f was constructed using metagenes YMH and YH, and microarrays Y and Hf. The network Y-M m -M f -H f was constructed using metagenes YMH and all four microarray studies.