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Figure 4 | BMC Systems Biology

Figure 4

From: A yeast's eye view of mammalian reproduction: cross-species gene co-expression in meiotic prophase

Figure 4

Characterizations of metagene pairs and metagenes using yeast genomic information. Top metagene pairs are the pairs with the most significant P-values for co-expression across species. The random curves with mean and standard deviation labeled were derived from 100 trials of randomly permuting metagene pairs in each network. A. Yeast metagene pairs co-localized in the same protein complex. The observed curve is significantly different from the randomized curve for all networks except Y-M f (Welch Two Sample t-test P < 0.05). B. Yeast metagene pairs overlapping with protein interactions. The observed curve is significantly different from the randomized curve for all four networks (Welch Two Sample t-test P < 0.05). C. Averaged semantic similarity of yeast metagene pairs calculated using GO sub-ontology Biological Process. The observed curve is significantly different from the randomized curve for all four networks (Welch Two Sample t-test P < 0.05). D. Yeast metagenes overlapping with essential genes. The observed curve is significantly different from the randomized curve for all four networks (Welch Two Sample t-test P < 0.05).

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