TY - JOUR AU - Dexter, Tim J. AU - Sims, David AU - Mitsopoulos, Costas AU - Mackay, Alan AU - Grigoriadis, Anita AU - Ahmad, Amar S. AU - Zvelebil, Marketa PY - 2010 DA - 2010/09/08 TI - Genomic distance entrained clustering and regression modelling highlights interacting genomic regions contributing to proliferation in breast cancer JO - BMC Systems Biology SP - 127 VL - 4 IS - 1 AB - Genomic copy number changes and regional alterations in epigenetic states have been linked to grade in breast cancer. However, the relative contribution of specific alterations to the pathology of different breast cancer subtypes remains unclear. The heterogeneity and interplay of genomic and epigenetic variations means that large datasets and statistical data mining methods are required to uncover recurrent patterns that are likely to be important in cancer progression. SN - 1752-0509 UR - https://doi.org/10.1186/1752-0509-4-127 DO - 10.1186/1752-0509-4-127 ID - Dexter2010 ER -